Hydrazine hydrate (1:1) → (E)-(3,5-dibromo-4-pyridinyl)methylidenehydrazine
反応式
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Br:10])[C:7]=1[CH:8]=O.O.[NH2:12][NH2:13]>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Br:10])[C:7]=1/[CH:8]=[N:12]/[NH2:13]参加物
3
反応条件
- 温度
- 120 °C
実験手順
In analogy to GP 1, 54 mg of 3,5-dibromo-pyridine-4-carbaldehyde (0.2 mmol, 1 eq; commercially available or prepared as described in U.S. Pat. No. 6,232,320 or WO2005110410) were dissolved in 1 mL 1-propyl alkohol, treated with 30 μL 80% hydrazine hydrate (0.61 mmol, 3 eq.) and heated to 120° C. for 30 min (employing a Biotage Initiator® microwave oven). The precipitate was filtered and washed with cold 1-propyl alkohol to yield 27 mg of the hydrazone (0.1 mmol, 50% yield).
後処理
- customcommercially available or prepared
- dissolution6,232,320 or WO2005110410) were dissolved in 1 mL 1-propyl alkohol
- filtrationThe precipitate was filtered
- washwashed with cold 1-propyl alkohol
出典と根拠
- ORDレコード
- ord-ad75458ae0144b3da9a10cb5ebaab4d6
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08481539B2
反応ノート
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