8-(Nitromethyl)-1,4-dioxaspiro[4.5]decan-8-ol → 8-(Aminomethyl)-1,4-dioxaspiro[4.5]decan-8-ol

HRID 44711

反応式

HRID 44711 の反応式
[N+:1]([CH2:4][C:5]1([OH:15])[CH2:14][CH2:13][C:8]2([O:12][CH2:11][CH2:10][O:9]2)[CH2:7][CH2:6]1)([O-])=O>C(O)C.[OH-].[OH-].[Pd+2]>[NH2:1][CH2:4][C:5]1([OH:15])[CH2:14][CH2:13][C:8]2([O:12][CH2:11][CH2:10][O:9]2)[CH2:7][CH2:6]1

参加物

4

反応物 1

HCID 468356938-(Nitromethyl)-1,4-dioxaspiro[4.5]decan-8-ol

生成物 1

HCID 434366478-(Aminomethyl)-1,4-dioxaspiro[4.5]decan-8-ol収率 530.2%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

A mixture of 8-(nitromethyl)-1,4-dioxaspiro[4.5]decan-8-ol (16.0 g, 13.8 mmol) and 20% palladium hydroxide on carbon (3.2 g) in ethanol (160 mL) was hydrogenated at 50 psi (3.5×105 Pa) for 5 d on a Parr apparatus. The reaction mixture was filtered through CELITE filter agent and the filtrate was concentrated to give 8-(aminomethyl)-1,4-dioxaspiro[4.5]decan-8-ol as a clear oil (13.7 g, 99%) that solidified upon standing overnight.

後処理

  1. filtrationThe reaction mixture was filtered through CELITE
  2. filtrationfilter agent
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-0ff3801676f94d86b0b9d9c7fda18e74
出典データセット
uspto-grants-2013_09
特許番号
US08541438B2

関連ノート

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