8-(Nitromethyl)-1,4-dioxaspiro[4.5]decan-8-ol → 8-(Aminomethyl)-1,4-dioxaspiro[4.5]decan-8-ol
反応式
[N+:1]([CH2:4][C:5]1([OH:15])[CH2:14][CH2:13][C:8]2([O:12][CH2:11][CH2:10][O:9]2)[CH2:7][CH2:6]1)([O-])=O>C(O)C.[OH-].[OH-].[Pd+2]>[NH2:1][CH2:4][C:5]1([OH:15])[CH2:14][CH2:13][C:8]2([O:12][CH2:11][CH2:10][O:9]2)[CH2:7][CH2:6]1参加物
4
実験手順
A mixture of 8-(nitromethyl)-1,4-dioxaspiro[4.5]decan-8-ol (16.0 g, 13.8 mmol) and 20% palladium hydroxide on carbon (3.2 g) in ethanol (160 mL) was hydrogenated at 50 psi (3.5×105 Pa) for 5 d on a Parr apparatus. The reaction mixture was filtered through CELITE filter agent and the filtrate was concentrated to give 8-(aminomethyl)-1,4-dioxaspiro[4.5]decan-8-ol as a clear oil (13.7 g, 99%) that solidified upon standing overnight.
後処理
- filtrationThe reaction mixture was filtered through CELITE
- filtrationfilter agent
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-0ff3801676f94d86b0b9d9c7fda18e74
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541438B2
反応ノート
読み込み中…