Methanol → HCID 67304384、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13](O)=[O:14])[N:10]=[CH:9]2)=[CH:4][CH:3]=1.CO>C1COCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([CH2:13][OH:14])[N:10]=[CH:9]2)=[CH:6][CH:7]=1参加物
4
実験手順
1-(4-Fluoro-phenyl)-1H-imidazole-4-carboxylic acid is dissolved in THF. Borane tetrahydrofuran complex in THF is added dropwise. The reaction is refluxed for 2 h and stirred at room temperature overnight. The reaction mixture is then cooled to 0° C. and methanol is added dropwise. The solvents are evaporated and the residue is taken up in HCl and refluxed for 2 h. The reaction mixture is then cooled to 0° C. and sodium hydroxide solution is added dropwise. The desired compound [1-(4-fluoro-phenyl)-1H-imidazol-4-yl]-methanol is obtained.
後処理
- temperatureThe reaction is refluxed for 2 h
- temperatureThe reaction mixture is then cooled to 0° C.
- customThe solvents are evaporated
- temperaturerefluxed for 2 h
- temperatureThe reaction mixture is then cooled to 0° C.
- additionsodium hydroxide solution is added dropwise
出典と根拠
- ORDレコード
- ord-d0035ed09e9045f59fca3eb97361ce8b
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08481548B2
反応ノート
読み込み中…