Water → N'-(2-bromophenyl)sulfonyl-N,N-dimethylmethanimidamide

HRID 447222

反応式

HRID 447222 の反応式
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[Br:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[S:16]([NH2:19])(=[O:18])=[O:17].CN(C=O)C.S([O-])(O)(=O)=O.[Na+].O>>[Br:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[S:16](/[N:19]=[CH:3]/[N:4]([CH3:6])[CH3:5])(=[O:18])=[O:17]

参加物

6

反応物 5

HCID 962WaterHCID 6228DimethylformamideHCID 78373Dimethylformamide dimethyl acetalHCID 516919Sodium BisulfateHCID 28012632-Bromobenzenesulfonamide

生成物 1

HCID 11779014N'-(2-bromophenyl)sulfonyl-N,N-dimethylmethanimidamide収率 96.6%

実験手順

1,1-Dimethoxy-N,N-dimethylmethanamine (14.6 mL, 104 mmol) was added to a solution of 2-bromobenzene-1-sulfonamide (20.4 g, 86.4 mmol) in DMF (56 mL, 720 mmol) and the resulting solution was stirred at room temperature for 90 minutes. A solution of sodium hydrogen sulfate (1.7 g, 14 mmol) in water (170 mL, 9.4 mol) was cooled at 0° C. and then added to the reaction mixture. The precipitate was filtered, washed with water, and dried to yield 2-bromo-N-[1-dimethylaminometh-(E)-ylidene]benzenesulfonamide (24.3 g) as a white solid.

後処理

  1. additionadded to the reaction mixture
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-a79242ee748e4b0b80a9bb94c7bad53b
出典データセット
uspto-grants-2013_07
特許番号
US08481549B2

関連ノート

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