Hydrochloric Acid → N-alpha-undec-10-enoyl-glutamic acid

HRID 447705

反応式

HRID 447705 の反応式
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])N.[OH-:11].[K+].[C:13](Cl)(=[O:24])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH:22]=[CH2:23].Cl>O.C1COCC1>[C:13]([NH:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5]([OH:11])=[O:7])(=[O:24])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH:22]=[CH2:23]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 5961L-GlutamineHCID 14797Potassium HydroxideHCID 3804210-Undecenoyl chloride

生成物 1

HCID 57102536N-alpha-undec-10-enoyl-glutamic acid収率 30%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
20 °C

実験手順

L-Glutamine (14.62 g, 0.1 mol) and KOH (11.2 g, 0.2 mol) were dissolved in water (200 mL) at 20° C. A solution of 10-undecenoyl chloride (20.3 g, 0.1 mol) in THF (200 mL) was then added over 10 minutes. The reaction was stirred for 16 hours at 20° C. and was then reduced in vacuo to a volume of approximately 250 mL. Concentrated HCl (circa 12M) was added dropwise until the solution was pH 1. The white solid precipitate was collected by filtration. This solid was washed with water (100 mL) and diethyl ether (100 mL). The solid was then dissolved in refluxing toluene (500 mL) and the excess water present was removed by distillation at ambient pressure using a Dean-Stark trap. The solution was then allowed to cool to 20° C. After 16 hours, the white solid precipitate was collected via filtration and recrystallized from EtOAc (500 mL). This solid was dried in vacuo to give N-α-undec-10-enoyl-glutamic acid (9.36 g, 30%) as a white powder.

後処理

  1. filtrationThe white solid precipitate was collected by filtration
  2. washThis solid was washed with water (100 mL) and diethyl ether (100 mL)
  3. dissolutionThe solid was then dissolved
  4. temperaturein refluxing toluene (500 mL)
  5. customthe excess water present was removed by distillation at ambient pressure
  6. temperatureto cool to 20° C
  7. waitAfter 16 hours
  8. filtrationthe white solid precipitate was collected via filtration
  9. customrecrystallized from EtOAc (500 mL)
  10. customThis solid was dried in vacuo

出典と根拠

ORDレコード
ord-ee5aa16d95954c82b22e7ecf7215dfa5
出典データセット
uspto-grants-2013_07
特許番号
US08481558B2

関連ノート

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