Dimethylformamide → 1,3-Difluoro-5-methoxy-2-nitrobenzene

HRID 447763ノート

反応式

HRID 447763 の反応式
[N+:1]([C:4]1[C:9]([F:10])=[CH:8][C:7]([OH:11])=[CH:6][C:5]=1[F:12])([O-:3])=[O:2].[C:13](=O)([O-])[O-].[K+].[K+].IC.CN(C)C=O>O.C(OCC)(=O)C>[N+:1]([C:4]1[C:5]([F:12])=[CH:6][C:7]([O:11][CH3:13])=[CH:8][C:9]=1[F:10])([O-:3])=[O:2]

参加物

7

反応物 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178437653,5-Difluoro-4-nitrophenol

生成物 1

HCID 100127101,3-Difluoro-5-methoxy-2-nitrobenzene

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 4-nitro-3,5-difluorophenol (D10) (440 mg, 2.5 mmol), potassium carbonate (600 mg, 4.6 mmol), iodomethane (1 ml), and dimethylformamide (5 ml) stirred overnight at room temperature then ethyl acetate and water added and the solution washed with water then dried over MgSO4, filtered and evaporated to yield the title compound, pale brown oil, 370 mg.

後処理

  1. washthe solution washed with water
  2. dry with materialthen dried over MgSO4
  3. filtrationfiltered
  4. customevaporated

出典と根拠

ORDレコード
ord-374ccba3e5084f579897e548854f4f79
出典データセット
uspto-grants-2013_07
特許番号
US08481566B2

反応ノート

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