Benzoyl Peroxide → 2-(Bromomethyl)-1-chloro-3-methoxybenzene

HRID 447920

反応式

HRID 447920 の反応式
[Cl:1][C:2]1[C:3]([CH3:10])=[C:4]([O:8][CH3:9])[CH:5]=[CH:6][CH:7]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Br:29]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[CH2:10][Br:29]

参加物

5

反応物 3

HCID 7187Benzoyl Peroxide2 回HCID 67184N-bromobutanimideHCID 767493-Chloro-2-methylanisole

生成物 1

HCID 223274432-(Bromomethyl)-1-chloro-3-methoxybenzene

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To 13.0 g (84.92 mmol) 3-chloro-2-methylanisole in 80 ml CCl4 at reflux were added 0.4 g dibenzoyl peroxide and then, subsequently and portion-wise, a mixture of 15.2 g N-bromosuccinimide and 0.4 g dibenzoyl peroxide. After completion of reaction the mixture was evaporation-concentrated, the residue was dissolved in dichloromethane, was sequentially washed with water and saturated NaCl solution, was dried over MgSO4, was filtered and again evaporation-concentrated. 20.8 yellow oil.

後処理

  1. customAfter completion of reaction the mixture
  2. concentrationwas evaporation-concentrated
  3. dissolutionthe residue was dissolved in dichloromethane
  4. washwas sequentially washed with water and saturated NaCl solution
  5. dry with materialwas dried over MgSO4
  6. filtrationwas filtered
  7. concentrationagain evaporation-concentrated

出典と根拠

ORDレコード
ord-64c8ff1a9d2146beb4c4a081d5052a32
出典データセット
uspto-grants-2013_07
特許番号
US08481576B2

関連ノート

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