(R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)amino)butanoate → (R)-methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate

HRID 44804

反応式

[Cl:1][C:2]1[N:7]=[C:6]([N:8]([CH:16]2[CH2:20]CC[CH2:17]2)[C@H:9]([CH2:14][CH3:15])[C:10]([O:12][CH3:13])=[O:11])[C:5]([N+:21]([O-:23])=[O:22])=[CH:4][N:3]=1>CC(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([N:8]([CH:16]([CH3:20])[CH3:17])[C@H:9]([CH2:14][CH3:15])[C:10]([O:12][CH3:13])=[O:11])[C:5]([N+:21]([O-:23])=[O:22])=[CH:4][N:3]=1

参加物

実験手順

Intermediate C-1 was prepared similarly to the synthetic methods used to prepare Intermediate A with the exception that acetone was used instead of cyclopentanone in the reductive amination step.

後処理

customIntermediate C-1 was prepared similarly to the synthetic methods

出典と根拠

ORDレコード: ord-3fd893af0d6544c4821cd0d1f8d7b325
出典データセット: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08541418B2

反応式

参加物

反応物 1

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート