Bromopinacolone → 3-(3,3-Dimethyl-2-oxobutyl)-2.4.5-trimethylthiazol-3-ium bromide
反応式
[CH3:1][C:2]1[S:3][C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1.[Br:9][CH2:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]>C(#N)C>[Br-:9].[CH3:13][C:12]([CH3:15])([CH3:14])[C:11](=[O:16])[CH2:10][N+:6]1[C:5]([CH3:7])=[C:4]([CH3:8])[S:3][C:2]=1[CH3:1]参加物
4
反応条件
- 温度
- 60 °C
実験手順
A mixture of 2,4,5-trimethylthiazole (640 mg, 5 mmol) and 1-bromo-3,3-dimethylbutan-2-one (1.8 g, 10 mmol) in anhydrous acetonitrile (20 mL) was stirred at 60° C. for 5 h. The mixture was then concentrated under reduced pressure, the residue was triturated with anhydrous ethyl ether and the solid was filtered and dried under reduced pressure to provide 1.4 g of the crude title compound.
後処理
- concentrationThe mixture was then concentrated under reduced pressure
- customthe residue was triturated with anhydrous ethyl ether
- filtrationthe solid was filtered
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-a7abddcb3d8d4a3caae50e5c40e12f68
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08481574B2
反応ノート
読み込み中…