HCID 519042、化合物 → 1-(2-methylthiazol-5-yl)ethanone
反応式
Br[C:2](=[C:6]([OH:8])[CH3:7])[C:3](=O)C.[C:9]([NH2:12])(=[S:11])[CH3:10]>CC(C)=O>[C:6]([C:2]1[S:11][C:9]([CH3:10])=[N:12][CH:3]=1)(=[O:8])[CH3:7]参加物
4
実験手順
To a solution of the product of Example 151B (14.5 g, 88 mmol) in acetone (220 mL) was added thioacetamide (6.6 g, 88 mmol) and stirred overnight. The solid was filtered to give the title compound as the hydrogen bromide salt. 1H NMR (300 MHz, DMSO-d6) δ ppm 2.54 (s, 3 H) 2.71 (s, 3 H) 8.46 (s, 1 H). MS (DCI) m/z 142 (M+H)+.
後処理
- filtrationThe solid was filtered
出典と根拠
- ORDレコード
- ord-7ce2d9ad574a4beea8cdfbe631fa4f0f
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08481574B2
反応ノート
読み込み中…