Trifluoroacetic acid → HCID 58405590、化合物

HRID 44853

反応式

HRID 44853 の反応式
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[N:17]=[CH:16][C:15]2[N:14]([CH3:18])[C:13](=[O:19])[C@@H:12]([CH2:20][CH3:21])[N:11]([CH:22]([CH3:24])[CH3:23])[C:10]=2[N:9]=1.[CH3:25][C:26]([CH3:32])([CH3:31])[CH2:27][C:28](O)=[O:29].C(O)(C(F)(F)F)=O>>[CH2:20]([C@H:12]1[N:11]([CH:22]([CH3:23])[CH3:24])[C:10]2[N:9]=[C:8]([C:7]3[CH:6]=[CH:5][N:4]=[CH:3][C:2]=3[NH:1][C:28](=[O:29])[CH2:27][C:26]([CH3:32])([CH3:31])[CH3:25])[N:17]=[CH:16][C:15]=2[N:14]([CH3:18])[C:13]1=[O:19])[CH3:21]

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 14057tert-Butylacetic acidHCID 58405288(R)-2-(3-aminopyridin-4-yl)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one

生成物 1

HCID 58405590HCID 58405590、化合物

実験手順

The title compound was prepared similarly to the methods described in Example 102, with (R)-2-(3-aminopyridin-4-yl)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 93) instead of (R)-2-(3-aminopyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 91) and with 3,3-dimethylbutanoic acid instead of benzoic acid. LCMS (0.05% TFA): 425.3 m/z (M+H)+; 1H-NMR (DMSO-d6, 500 MHz): δ: 12.93 (bs, 1H), 9.89 (bs, 1H), 8.50 (bs, 2H), 8.30 (s, 1H), 4.59 (m, 1H), 4.49 (m, 1H), 3.36 (s, 3H), 2.37 (s, 2H), 1.87 (m, 1H), 1.77 (m, 1H), 1.45 (m, 6H), 0.77 (t, 3H, J=7.5 Hz).

出典と根拠

ORDレコード
ord-6c7877ca90c24c70addba10c339b43a4
出典データセット
uspto-grants-2013_09
特許番号
US08541418B2

関連ノート

読み込み中…