反応式
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[N:17]=[CH:16][C:15]2[N:14]([CH3:18])[C:13](=[O:19])[C@@H:12]([CH2:20][CH3:21])[N:11]([CH:22]([CH3:24])[CH3:23])[C:10]=2[N:9]=1.[C:25](Cl)(=[O:27])[CH3:26].C(O)(C(F)(F)F)=O>>[CH2:20]([C@H:12]1[N:11]([CH:22]([CH3:23])[CH3:24])[C:10]2[N:9]=[C:8]([C:7]3[CH:6]=[CH:5][N:4]=[CH:3][C:2]=3[NH:1][C:25](=[O:27])[CH3:26])[N:17]=[CH:16][C:15]=2[N:14]([CH3:18])[C:13]1=[O:19])[CH3:21]参加物
4
実験手順
The title compound was prepared similarly to the methods described in Example 114, with (R)-2-(3-aminopyridin-4-yl)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 93) instead of (R)-2-(3-aminopyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 91) and with acetyl chloride instead of chloromethylcarbonate. LCMS (0.05% TFA): 369.1 m/z (M+H)+; 1H-NMR (DMSO-d6, 500 MHz): δ: 9.71 (s, 1H), 8.43 (d, 1H, J=5.0 Hz), 8.27 (d, 1H, J=5.0 Hz), 8.25 (s, 1H), 4.59 (m, 1H), 4.49 (m, 1H), 3.38 (s, 3H), 2.26 (s, 3H), 1.92 (m, 1H), 1.80 (m, 1H), 1.47 (t, 6H, J=6 Hz), 0.81 (t, 3H, J=7.5 Hz).
出典と根拠
- ORDレコード
- ord-fa9d388e18b44d52823a688017f7c7de
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541418B2
関連ノート
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