(2-Amino-6-fluorophenyl)methanol → 2-Amino-6-fluorobenzaldehyde
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][OH:10]>ClCCl.O=[Mn]=O>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH:9]=[O:10]参加物
4
実験手順
To (2-amino-6-fluoro-phenyl)-methanol (2.49 g, 17.3 mmol) in dichloromethane (30 mL) was added MnO2 (3.01 g, 34.7 mmol, activated). The mixture was refluxed for 3 hrs and then filtered over celite. The mixture was concentrated and purified via silica gel flash chromatography (eluting with 30% ethyl acetate in hexane) to give 2-amino-6-fluoro-benzaldehyde as a yellow solid (1.23 g). tR=2.20 min. (method 1)
後処理
- temperatureThe mixture was refluxed for 3 hrs
- filtrationfiltered over celite
- concentrationThe mixture was concentrated
- custompurified via silica gel flash chromatography (eluting with 30% ethyl acetate in hexane)
出典と根拠
- ORDレコード
- ord-4f5244801e9e415daa645eb9ccac5c3b
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08481738B2
反応ノート
読み込み中…