Nitrogen → 5-Methoxy-1,2,4-triazine-6-methanamine
反応式
N#N.[N:3]([CH2:6][C:7]1[N:12]=[N:11][CH:10]=[N:9][C:8]=1[O:13][CH3:14])=[N+]=[N-]>[Pd].CO>[CH3:14][O:13][C:8]1[N:9]=[CH:10][N:11]=[N:12][C:7]=1[CH2:6][NH2:3]参加物
5
実験手順
A flask filled with N2 was charged with 6-(azidomethyl)-5-methoxy-1,2,4-triazine (15.0 g, 0.0903 mol) and Pd/C (10%) (3.20 g) followed by MeOH (480 mL). The suspension was purged with N2. The reaction was then stirred under H2 (1 atm) at rt for 5 h. The inorganics were filtered off, the solvent was removed under reduced pressure to give 1-(5-methoxy-[1,2,4]triazin-6-yl)-methylamine which was used for next step without any further purification.
後処理
- customThe suspension was purged with N2
- filtrationThe inorganics were filtered off
- customthe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-b829347c844845b08b2d6e3fe7dac954
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08481733B2
反応ノート
読み込み中…