Dichloromethane → HCID 57171531、化合物

HRID 449118

反応式

HRID 449118 の反応式
[CH2:1]([C:3]1[CH:4]=[C:5]([OH:10])[CH:6]=[CH:7][C:8]=1[Cl:9])[CH3:2].[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(Cl)Cl>>[Cl:9][C:8]1[CH:7]=[CH:6][C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][C:3]=1[CH2:1][CH3:2]

参加物

4

反応物 3

HCID 6344DichloromethaneHCID 66827Phenylboronic AcidHCID 842234-Chloro-3-ethylphenol

生成物 1

HCID 57171531HCID 57171531、化合物

実験手順

3-ethyl-4-chlorophenol (2.0 g, 0.013 mol), phenylboronic acid (4.7 g, 0.038 mol), TEA (11 mL, 0.077 mol), cupric acetate (4.2 g, 0.023 mol) and DCM (60 mL, 0.9 mol) were added to a 100 mL oven dried flask and the reaction was stirred at rt for 24 h. The solvent was then removed under reduced pressure and the resulting residue was purified by flash chromatography (5% EtOAc in Hexane).

後処理

  1. customdried flask
  2. customThe solvent was then removed under reduced pressure
  3. customthe resulting residue was purified by flash chromatography (5% EtOAc in Hexane)

出典と根拠

ORDレコード
ord-468ee86025da4a8694d036ab3c535b72
出典データセット
uspto-grants-2013_07
特許番号
US08481733B2

関連ノート

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