Dichloromethane → 1-Chloro-2-ethyl-4-phenoxybenzene
反応式
[CH2:1]([C:3]1[CH:4]=[C:5]([OH:10])[CH:6]=[CH:7][C:8]=1[Cl:9])[CH3:2].[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(Cl)Cl>>[Cl:9][C:8]1[CH:7]=[CH:6][C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][C:3]=1[CH2:1][CH3:2]参加物
4
実験手順
3-ethyl-4-chlorophenol (2.0 g, 0.013 mol), phenylboronic acid (4.7 g, 0.038 mol), TEA (11 mL, 0.077 mol), cupric acetate (4.2 g, 0.023 mol) and DCM (60 mL, 0.9 mol) were added to a 100 mL oven dried flask and the reaction was stirred at rt for 24 h. The solvent was then removed under reduced pressure and the resulting residue was purified by flash chromatography (5% EtOAc in Hexane).
後処理
- customdried flask
- customThe solvent was then removed under reduced pressure
- customthe resulting residue was purified by flash chromatography (5% EtOAc in Hexane)
出典と根拠
- ORDレコード
- ord-468ee86025da4a8694d036ab3c535b72
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08481733B2
反応ノート
読み込み中…