1-Isopropyl-4-(6-nitropyridin-3-yl)piperazine → 5-(4-(Propan-2-yl)piperazin-1-yl)pyridin-2-amine

HRID 449609ノート

反応式

HRID 449609 の反応式
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:11]=[N:12][C:13]([N+:16]([O-])=O)=[CH:14][CH:15]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]>CCO.[Pd]>[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12][CH:11]=2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 575020971-Isopropyl-4-(6-nitropyridin-3-yl)piperazine

生成物 1

HCID 434619445-(4-(Propan-2-yl)piperazin-1-yl)pyridin-2-amine収率 61.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

In a 250 mL round-bottomed flask, 1-isopropyl-4-(6-nitropyridin-3-yl)piperazine (788 mg, 3.15 mmol, Eq: 1.00) in EtOH (40 ml) was combined with palladium on carbon (DeGussa)(78.2 mg, 735 μmol, Eq: 0.233). The mixture was evacuated twice with hydrogen and then stirred under a hydrogen atmosphere for 18 h. The solution was filtered through celite, rinsing the celite with fresh ethanol. The solvent was evaporated under reduced pressure to give 5-(4-isopropylpiperazin-1-yl)pyridin-2-amine (425 mg, 61%). LC/MS-ESI observed [M+H]+ 221.

後処理

  1. customThe mixture was evacuated twice with hydrogen
  2. filtrationThe solution was filtered through celite
  3. washrinsing the celite with fresh ethanol
  4. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-141944ccc63f4873b599b9cf47ff11dc
出典データセット
uspto-grants-2013_07
特許番号
US08481540B2

反応ノート

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