Lamotrigine → 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxybutanedioate

HRID 449792ノート

反応式

HRID 449792 の反応式
[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[Na+].[C:18]([O-:26])(=[O:25])[CH:19]([CH2:21][C:22]([O-:24])=[O:23])[OH:20].[Na+]>CO>[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[C:18]([O-:26])(=[O:25])[CH:19]([CH2:21][C:22]([O-:24])=[O:23])[OH:20]

参加物

4

反応物 2

HCID 3878LamotrigineHCID 8736Malic acid, disodium salt

生成物 1

HCID 866323236-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxybutanedioate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

20 mg of lamotrigine was dissolved in 2 ml of methanol, 12 mg of malic acid sodium salt was added to the solution to form a single solution. The solution was then allowed to stand for several hours to effect the slow evaporation of solvent. The solids gathered were stored in screw cap vials for subsequent analysis.

後処理

  1. customto form a single solution
  2. waitto stand for several hours
  3. customthe slow evaporation of solvent
  4. customcap vials for subsequent analysis

出典と根拠

ORDレコード
ord-1bfa01b5902049028c09a97c1103eb66
出典データセット
uspto-grants-2013_07
特許番号
US08486927B2

反応ノート

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