Malic acid, disodium salt (HCID 8736)

概要

On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Malic Acid and Sodium Malate are safe for use as pH adjusters in cosmetic formulations. The Expert Panel determined that the data are insufficient to determine the safety of these ingredients for any other functions.

名称と識別子

優先名称: Malic acid, disodium salt
IUPAC: disodium;2-hydroxybutanedioate
現地名: DL-リンゴ酸二ナトリウム水和物
英語名: DL-Malic acid disodium salt
分子式: C4H4Na2O5
分子量: 178.05

名称と別名

Malic acid, disodium saltRefChem:887666Sodium malate676-46-0Disodium malateDL-Malic acid disodium saltdisodium 2-hydroxybutanedioateDisodium DL-malate22798-10-3disodium;2-hydroxybutanedioateSODIUM DL-MALATESodium 2-hydroxysuccinate

名称をさらに表示

DL-リンゴ酸二ナトリウム水和物rac-(R*)-2-ヒドロキシブタン二酸ジナトリウムDL-りんご酸ジナトリウムりんご酸二ナトリウム?0.5水りんご酸二ナトリウム・0.5水DISODIUM DL-MALATE HYDRATEMALIC ACID, SODIUMDI-SODIUM DL-MALATEDL-MALIC ACID SODIUMMalicaciddisodiumsaltdl-malic acid disodiumDl-MalicAcid,SodiumSaltSODIUM DL-MALATE HYDRATEDI-SODIUM MALATE 0.5-WATER

Sodium DL-maleateButanedioic acid, hydroxy-, disodium saltDTXSID7046831malic acid sodium saltMFCD00012466L-HYDROXYBUTANEDIOICACIDDISODIUMSALT2EFF9N315F63474-37-3

データベース識別子

CAS: 22798-10-3、40520-93-2、676-46-0
PubChem CID: 8736
DTXSID: DTXSID7046831
ChEMBL: CHEMBL182856
UNII: 2EFF9N315F
EC Number: 211-627-6、254-952-9、866-020-4
Nikkaji: J3.317K

物性

構造計算による物性

極性表面積: 100 Å²
水素結合供与体数: 1
水素結合受容体数: 5
回転可能結合数: 1
重原子数: 11
形式電荷: 0
複雑度: 118

実験および物理化学的性質

Cosmetics · 2 件

Cosmetic ingredients (Sodium Malate) -> CIR (Cosmetic Ingredient Review)

Humectant; Skin conditioning

SolubilityFreely soluble in water

Physical DescriptionWhite crystalline powder or lumps

物理化学的性質

融点: 300 °C · >300 °C(lit.)
CAS データベース: 22798 · 22798-10-3(CAS DataBase Reference)

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 45.8% (65 of 142) of reports.

Warning

H315 (41.5%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 142 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

This chemical does not meet GHS hazard criteria for 100% (37 of 37) of all reports.

危険有害性情報

Regulatory Information · 2 件

Chemical: Butanedioic acid, hydroxy-, disodium salt

Disodium malate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Butanedioic acid, hydroxy-, disodium salt: Human health tier I assessment

Hazard Classes and Categories · 3 件

Skin Irrit. 2 (41.5%)

Skin Irrit. 2 (100%)

Not Classified

毒性情報

Toxicity Summary · 2 件

On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Malic Acid and Sodium Malate are safe for use as pH adjusters in cosmetic formulations. The Expert Panel determined that the data are insufficient to determine the safety of these ingredients for any other functions.

Safe for use in cosmetics, with qualifications

安全データ

wgk: 3
rtecs: ON7730000

化学と産業

用途と製造

UsesCIR ingredient: Sodium Malate

Use Classification · 4 件

Food additives

Flavouring Agent -> FLAVOURING_AGENTFood Additives -> ACIDITY_REGULATOR -> JECFA Functional Classes

Cosmetics -> Humectant; Skin conditioning

サプライヤー50 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]

湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]

上海康朗生物科技有限公司021-61998208 18217752821 · [email protected]

上海哲研生物科技有限公司021-18017610038 18017610038 · [email protected]

江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]

DL-リンゴ酸二ナトリウム水和物

基本情報

概要