Dimethylamine → HCID 67128887、化合物

HRID 449923

反応式

HRID 449923 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](O)=[O:12])[CH:8]=[C:7]([Cl:14])[C:3]=1[C:4]([OH:6])=[O:5].C1N=[CH:18][N:17](C(N2C=NC=C2)=O)[CH:16]=1.CNC>ClC1CC(C(C)C)CCC1(Cl)C>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:12])[N:17]([CH3:18])[CH3:16])[CH:8]=[C:7]([Cl:14])[C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 674DimethylamineHCID 39047Benzenedicarboxylic acid, dichloro-HCID 682631,1'-Carbonyldiimidazole

生成物 1

HCID 67128887HCID 67128887、化合物

試薬・触媒・溶媒 1

HCID 21946423Dichloromenthane溶媒

実験手順

To a solution of 2,6-dichloroterephthalic acid (100 mg, 0.46 mmol) in dichloromenthane was added CDI (62 mg, 0.46 mmol) in one portion. The reaction mixture was stirred at room temperature for 1.5 hours and then dimethyl amine (1.0 M in THF, 2 mL, 2.0 mmol) was added. The reaction was concentrated under reduced pressure to give the crude 2,6-dichloro-4-(dimethylcarbamoyl)benzoic acid, which was used in the next step without further purification. 1H NMR (500 MHz, DMSO-d6): δ 14.35 (s, 1H), 7.56 (s, 2H), 2.97 (s, 3H), 2.89 (s, 3H).

後処理

  1. concentrationThe reaction was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-763c3c867a3e45b58807a5388d5794a5
出典データセット
uspto-grants-2013_07
特許番号
US08486950B2

関連ノート

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