Thionyl Chloride → 2,6-Dichloro-4-(dimethylcarbamoyl)benzoyl chloride

HRID 449924ノート

反応式

HRID 449924 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:15])[N:12]([CH3:14])[CH3:13])[CH:8]=[C:7]([Cl:16])[C:3]=1[C:4](O)=[O:5].O=S(Cl)[Cl:19]>>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:15])[N:12]([CH3:14])[CH3:13])[CH:8]=[C:7]([Cl:16])[C:3]=1[C:4]([Cl:19])=[O:5]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 671288872,6-Dichloro-4-(dimethylcarbamoyl)benzoic acid

生成物 1

HCID 866489622,6-Dichloro-4-(dimethylcarbamoyl)benzoyl chloride収率 100%

実験手順

A solution of 2,6-dichloro-4-(dimethylcarbamoyl)benzoic acid (65 mg, 0.21 mmol) in SOCl2 (3 mL) was heated to reflux for overnight and then cooled to room temperature. The mixture was concentrated under reduced pressure to give crude 2,6-dichloro-4-(dimethylcarbamoyl)benzoyl chloride (70 mg, yield: 100%), which was used in the next step without further purification.

後処理

  1. temperatureto reflux for overnight
  2. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-4d307f5cca2e408dab15fb76c86b15f4
出典データセット
uspto-grants-2013_07
特許番号
US08486950B2

反応ノート

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