Ammonia → 4-Aminobenzamide

HRID 450033

反応式

HRID 450033 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH3:11]>O1CCCC1>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:11])=[O:7])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 177720Benzoyl chloride, 4-amino-

生成物 1

HCID 760794-Aminobenzamide収率 30%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To an ice-cold solution of 4-amino-benzoyl chloride (0.38 g, 2.45 mmol) in tetrahydrofuran (2 ml) was added aqueous ammonia solution (15 ml). The reaction mixture was stirred at room temperature for 12 hr. The solvent was removed under vacuum, water added and the compound was extracted into ethyl acetate. The organic layer was dried and concentrated under vacuum. The crude compound was purified using silica gel column chromatography, using chloroform/methanol as eluent, to yield 4-amino-benzamide (0.1 g, 30%).

後処理

  1. customThe solvent was removed under vacuum, water
  2. additionadded
  3. extractionthe compound was extracted into ethyl acetate
  4. customThe organic layer was dried
  5. concentrationconcentrated under vacuum
  6. customThe crude compound was purified

出典と根拠

ORDレコード
ord-77b9532ce9694d63ae78c3ee0bbc54e6
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

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