2-Methyl-2-(3-nitrophenyl)propanenitrile → 2-(3-Aminophenyl)-2-methylpropanenitrile
反応式
[CH3:1][C:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=1)([CH3:5])[C:3]#[N:4]>CO.[Pd]>[NH2:12][C:8]1[CH:7]=[C:6]([C:2]([CH3:5])([CH3:1])[C:3]#[N:4])[CH:11]=[CH:10][CH:9]=1参加物
4
実験手順
2-Methyl-2-(3-nitrophenyl)-propionitrile (0.5 g) was hydrogenated over 10% Pd—C in methanol (10 ml) at atmospheric pressure until no further gas uptake was observed. The reaction mixture was then filtered over celite and concentrated to oil. Column chromatography over silica gel by eluting with ethyl acetate/pet ether (1:9) gave 2-(3-amino-phenyl)-2-methyl-propionitrile (0.35 g, 83%) as an oil.
後処理
- filtrationThe reaction mixture was then filtered over celite and
- concentrationconcentrated to oil
- washColumn chromatography over silica gel by eluting with ethyl acetate/pet ether (1:9)
出典と根拠
- ORDレコード
- ord-50019a57dca74cb8b5b61346fdd62c11
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486962B2
反応ノート
読み込み中…