Water → 1H-Indole, 2,3-dihydro-1-methyl-5-nitro-

HRID 450044

反応式

HRID 450044 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH2:8][CH2:7]2)([O-:3])=[O:2].[OH-].[K+].[CH3:15]I.O>CC(C)=O>[CH3:15][N:9]1[C:10]2[C:6](=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)[CH2:7][CH2:8]1

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 362195-Nitroindoline

生成物 1

HCID 1677381H-Indole, 2,3-dihydro-1-methyl-5-nitro-収率 92.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 5-nitro-2,3-dihydro-1H-indole (1 g, 6.09 mmol) in acetone (12 ml) was added powdered potassium hydroxide (1.7 g, 30.45 mmol), followed by methyl iodide (1.2 g, 9.14 mmol) and stirred overnight at ambient temperature. The solvent was evaporated under vacuum to give a residue, to which water was added and the product extracted with ethyl acetate. Drying and concentration of the organic layer yielded 1-methyl-5-nitro-2,3-dihydro-1H-indole (1 g, 92%) as solid.

後処理

  1. customThe solvent was evaporated under vacuum
  2. customto give a residue
  3. extractionthe product extracted with ethyl acetate
  4. customDrying

出典と根拠

ORDレコード
ord-d7a933c1cbea496898453122ccff6b34
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

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