1-(Methylsulfonyl)-4-nitrobenzene → 4-(Methylsulfonyl)aniline

HRID 450051ノート

反応式

HRID 450051 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:3])=[O:4]

参加物

4

反応物 1

HCID 2584341-(Methylsulfonyl)-4-nitrobenzene

生成物 1

HCID 796174-(Methylsulfonyl)aniline収率 65%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 1-methanesulfonyl-4-nitro-benzene (500 mg, 2.48 mmol) in methanol (20 ml) was hydrogenated over 10% Pd—C (100 mg) at atmospheric pressure until no further gas uptake was observed. The reaction mixture was then filtered over celite and concentrated to give a residue, which was recrystallized from ethanol to yield 4-methanesulphonyl-phenylamine (276 mg, 65%) as solid.

後処理

  1. filtrationThe reaction mixture was then filtered over celite and
  2. concentrationconcentrated
  3. customto give a residue, which
  4. customwas recrystallized from ethanol

出典と根拠

ORDレコード
ord-473679a4a6794f9a8bc325647e04b223
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

反応ノート

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