Ethyl 2-(3-nitrophenoxy)acetate → Ethyl 2-(3-aminophenoxy)acetate
反応式
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-])=O)[CH:8]=1)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH2:13])[CH:8]=1)[CH3:2]参加物
4
実験手順
A solution of (3-nitrophenoxy)-acetic acid ethyl ester (500 mg, 2.22 mmol) in methanol (20 ml) was hydrogenated over 10% Pd—C (50 mg) at atmospheric pressure until no further gas uptake was observed. The reaction mixture was then filtered over celite and concentrated to yield a residue which was purified over neutral alumina using ethyl acetate-hexane to give (3-amino-phenoxy)-acetic acid ethyl ester (330 mg, 77%) as oil.
後処理
- filtrationThe reaction mixture was then filtered over celite and
- concentrationconcentrated
- customto yield a residue which
- customwas purified over neutral alumina
出典と根拠
- ORDレコード
- ord-56698f46ec324d218ba3f9e3adbc8585
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486962B2
反応ノート
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