Ethyl 2-(3-nitrophenoxy)acetate → Ethyl 2-(3-aminophenoxy)acetate

HRID 450053

反応式

HRID 450053 の反応式
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-])=O)[CH:8]=1)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH2:13])[CH:8]=1)[CH3:2]

参加物

4

反応物 1

HCID 2741030Ethyl 2-(3-nitrophenoxy)acetate

生成物 1

HCID 412308Ethyl 2-(3-aminophenoxy)acetate収率 77%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of (3-nitrophenoxy)-acetic acid ethyl ester (500 mg, 2.22 mmol) in methanol (20 ml) was hydrogenated over 10% Pd—C (50 mg) at atmospheric pressure until no further gas uptake was observed. The reaction mixture was then filtered over celite and concentrated to yield a residue which was purified over neutral alumina using ethyl acetate-hexane to give (3-amino-phenoxy)-acetic acid ethyl ester (330 mg, 77%) as oil.

後処理

  1. filtrationThe reaction mixture was then filtered over celite and
  2. concentrationconcentrated
  3. customto yield a residue which
  4. customwas purified over neutral alumina

出典と根拠

ORDレコード
ord-56698f46ec324d218ba3f9e3adbc8585
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

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