(4-Nitrophenyl)acetic acid → Benzeneacetyl chloride, 4-nitro-

HRID 450077

反応式

HRID 450077 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)([Cl:16])=O>C1C=CC=CC=1>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([Cl:16])=[O:13])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 4661(4-Nitrophenyl)acetic acidHCID 24386Thionyl Chloride

生成物 1

HCID 6452210Benzeneacetyl chloride, 4-nitro-収率 91%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To mixture of p-nitrophenylacetic acid (1 g, 5.5 mmol) in benzene (10 ml) was added thionyl chloride (0.8 ml) at room temperature. The reaction mixture was heated to reflux for 12 hr and then cooled. The excess thionyl chloride and benzene were removed in vacuo to obtain (4-nitro-phenyl)-acetyl chloride (1 g, 91%).

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 12 hr
  3. temperaturecooled
  4. customThe excess thionyl chloride and benzene were removed in vacuo

出典と根拠

ORDレコード
ord-f9c31a1a115c401fa9f3dac308421650
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

読み込み中…