1-(4-Nitrophenyl)propan-2-one → 4-Aminophenylacetone

HRID 450079

反応式

HRID 450079 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](=[O:13])[CH3:12])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11](=[O:13])[CH3:12])=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 2193671-(4-Nitrophenyl)propan-2-one

生成物 1

HCID 117883794-Aminophenylacetone収率 48%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

1-(4-nitro-phenyl)-propan-2-one (150 mg) was dissolved in methanol (5 ml) and then Pd/C (50 mg) was added. The resulting reaction mixture was stirred for 10 hr at room temperature under hydrogen pressure. The reaction mixture was filtered over celite and the filtrate evaporated. Purification by column chromatography over silica gel using ethyl acetate and hexane (1:9) as eluent gave 1-(4-amino-phenyl)-propan-2-one (60 mg, 48%).

後処理

  1. customThe resulting reaction mixture
  2. filtrationThe reaction mixture was filtered over celite
  3. customthe filtrate evaporated
  4. customPurification by column chromatography over silica gel

出典と根拠

ORDレコード
ord-a0e0548b7b274966b0f7a67c197f26de
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

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