1-(4-Nitrophenyl)propan-2-one → 4-Aminophenylacetone
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](=[O:13])[CH3:12])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11](=[O:13])[CH3:12])=[CH:8][CH:9]=1参加物
4
実験手順
1-(4-nitro-phenyl)-propan-2-one (150 mg) was dissolved in methanol (5 ml) and then Pd/C (50 mg) was added. The resulting reaction mixture was stirred for 10 hr at room temperature under hydrogen pressure. The reaction mixture was filtered over celite and the filtrate evaporated. Purification by column chromatography over silica gel using ethyl acetate and hexane (1:9) as eluent gave 1-(4-amino-phenyl)-propan-2-one (60 mg, 48%).
後処理
- customThe resulting reaction mixture
- filtrationThe reaction mixture was filtered over celite
- customthe filtrate evaporated
- customPurification by column chromatography over silica gel
出典と根拠
- ORDレコード
- ord-a0e0548b7b274966b0f7a67c197f26de
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486962B2
反応ノート
読み込み中…