1-(2-Methoxy-5-nitrophenyl)ethanone → 1-(5-Amino-2-methoxyphenyl)ethanone
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][C:4]=1[C:12](=[O:14])[CH3:13]>CO.[Pd]>[NH2:9][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[C:4]([C:12](=[O:14])[CH3:13])[CH:5]=1参加物
4
実験手順
A solution of 1-(2-methoxy-5-nitro-phenyl)-ethanone (350 mg, 1.8 mmol) in methanol (20 ml) was hydrogenated over 10% Pd—C (70 mg) at atmospheric pressure until no further absorption of gas took place. The reaction mixture was then filtered over celite and the filtrate concentrated under reduced pressure to give 1-(5-amino-2-methoxy-phenyl)-ethanone (250 mg, 85%) as a solid.
後処理
- filtrationThe reaction mixture was then filtered over celite
- concentrationthe filtrate concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-01951a74e7a14468b127ffea014f6606
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486962B2
反応ノート
読み込み中…