Hydrochloric Acid → 4-(2-Hydroxyethyl)cyclohexan-1-one

HRID 45012

反応式

HRID 45012 の反応式
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][OH:13])[CH2:7][CH2:6]2)OCC1.C1COCC1.Cl.C([O-])(O)=O.[Na+]>CC(C)=O>[OH:13][CH2:12][CH2:11][CH:8]1[CH2:9][CH2:10][C:5](=[O:1])[CH2:6][CH2:7]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 516892Sodium BicarbonateHCID 118054582-(1,4-Dioxaspiro(4.5)decan-8-yl)ethan-1-ol

生成物 1

HCID 157003924-(2-Hydroxyethyl)cyclohexan-1-one

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
25 °C

実験手順

2-(1,4-Dioxaspiro[4.5]dec-8-yl)ethanol (2.70 g, 0.0145 mol) was dissolved in acetone (10.00 mL) and THF (10.00 mL) and 6.00 M HCl (6.00 mL) was added. The reaction was stirred at 25° C. for 16 hours, neutralized with NaHCO3 solution and was then extracted with ethyl acetate. The organic extracts were washed with water, and with saturated NaCl, then dried (MgSO4) and concentrated in vacuo. The crude product was used in the next reaction without further purification. 1H NMR(CDCl3): 3.75 (m, 2H), 2.36 (m, 4H), 1.20-2.13 (m, 7H).

後処理

  1. extractionwas then extracted with ethyl acetate
  2. washThe organic extracts were washed with water
  3. dry with materialwith saturated NaCl, then dried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customThe crude product was used in the next reaction without further purification

出典と根拠

ORDレコード
ord-ab5b9732bfe747209e2c3cbda0178206
出典データセット
uspto-grants-2013_09
特許番号
US08541425B2

関連ノート

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