2-Methoxy-5-nitropyrimidine → 2-Methoxypyrimidin-5-amine

HRID 450180

反応式

HRID 450180 の反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][N:4]=1>CO.[Pd]>[NH2:9][C:6]1[CH:5]=[N:4][C:3]([O:2][CH3:1])=[N:8][CH:7]=1

参加物

4

反応物 1

HCID 3529002-Methoxy-5-nitropyrimidine

生成物 1

HCID 3529042-Methoxypyrimidin-5-amine収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To 0.342 g (2.20 mmol) of the above nitro compound in MeOH (20 mL) was added 0.30 g of 10% Pd/C and the mixture was stirred under hydrogen (25 in/Hg) for 18 hrs. The reaction mixture was filtered through celite, and concentrated, to give 0.274 g (100% yield) of 5-amino-2-methoxypyrimidine as a colorless oil: 1H NMR (DMSO-d6) δ 8.05 (s, 2H), 3.94 (s, 3H); LCMS (APCI+) m/z: 126 (MH+, 100%).

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-baaf8f4908814131a2da245bbc3ce777
出典データセット
uspto-grants-2013_07
特許番号
US08486939B2

関連ノート

読み込み中…