Ammonia → 2,4-Dichloro-5-fluoro-3-nitrobenzamide

HRID 450329

反応式

HRID 450329 の反応式
[NH3:1].[Cl:2][C:3]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10]([Cl:15])[C:9]([F:16])=[CH:8][C:4]=1[C:5](Cl)=[O:6]>C1COCC1>[Cl:2][C:3]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10]([Cl:15])[C:9]([F:16])=[CH:8][C:4]=1[C:5]([NH2:1])=[O:6]

参加物

4

反応物 2

HCID 222AmmoniaHCID 11818130Benzoyl chloride, 2,4-dichloro-5-fluoro-3-nitro-

生成物 1

HCID 866744942,4-Dichloro-5-fluoro-3-nitrobenzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

32%-aq. NH3-solution (250 mL) is dropped to 2,4-dichloro-5-fluoro-3 nitro-benzoic acid chloride (16.0 g, 59 mmol) in 100 mL THF and it is stirred for 20 min. Then the mixture is concentrated and the resulting precipitate is collected and dried.

後処理

  1. concentrationThen the mixture is concentrated
  2. customthe resulting precipitate is collected
  3. customdried

出典と根拠

ORDレコード
ord-df08f57c65574d2dac6a5cf4ec7a4982
出典データセット
uspto-grants-2013_07
特許番号
US08486968B2

関連ノート

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