HCID 178482395、化合物 → HCID 178482394、化合物
反応式
[F:1][C:2]([F:34])([F:33])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:32])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH:20][CH3:21])=[N:13][C:12]=2[N:22]2[CH2:27][CH2:26][CH:25]([C:28]([F:31])([F:30])[F:29])[CH2:24][CH2:23]2)[CH2:5][CH2:4]1>[Ni].C1COCC1>[F:34][C:2]([F:1])([F:33])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:32])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:20][CH3:21])=[N:13][C:12]=2[N:22]2[CH2:23][CH2:24][CH:25]([C:28]([F:30])([F:31])[F:29])[CH2:26][CH2:27]2)[CH2:5][CH2:4]1参加物
4
実験手順
A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-nitro-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide (120 mg, 0.24 mmol), Ra—Ni (30 mg) and THF (20 mL) is stirred under 50 psi H2-atmosphere for 4 h. The mixture is filtered, and the filtrate is concentrated.
後処理
- filtrationThe mixture is filtered
- concentration