Triethylamine → HCID 178458609、化合物

HRID 450358ノート

反応式

HRID 450358 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[N:3]=1.[CH:12]([O:15][C:16]1[NH:20][N:19]=[C:18]([NH2:21])[CH:17]=1)([CH3:14])[CH3:13].C(N(CC)CC)C>C(#N)C>[Cl:11][C:4]1[N:3]=[C:2]([NH:21][C:18]2[CH:17]=[C:16]([O:15][CH:12]([CH3:14])[CH3:13])[NH:20][N:19]=2)[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 852392,6-Dichloro-3-nitropyridineHCID 1784587215-Isopropoxy-1H-pyrazol-3-amine2 回

生成物 1

HCID 178458609HCID 178458609、化合物収率 61%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 2,6-dichloro-3-nitropyridine (0.5 g) and 5-isopropoxy-1H-pyrazol-3-amine (Intermediate 6, 0.35 g) in acetonitrile (10 mL) with triethylamine (2 mL) was stirred at room temperature for 24 hours, The resulting mixture was concentrated, and the resulting residue was separated by silica gel column (Hexane/Ethyl acetate) to afford 0.45 g desired product. MS (electrospray): 298 (M+1) for C11H12ClN5O3.

後処理

  1. concentrationThe resulting mixture was concentrated
  2. customthe resulting residue was separated by silica gel column (Hexane/Ethyl acetate)

出典と根拠

ORDレコード
ord-a0aae902817c4d5da4a907ee2478f91a
出典データセット
uspto-grants-2013_07
特許番号
US08486966B2

反応ノート

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