Chlorosulfonic acid → 3-Bromo-4-(trifluoromethoxy)benzenesulfonyl chloride

HRID 450715ノート

反応式

HRID 450715 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][C:9]([F:12])([F:11])[F:10].[Cl:13][S:14](O)(=[O:16])=[O:15]>ClCCl.CCCCCCC.ClCCl>[Br:1][C:2]1[CH:7]=[C:6]([S:14]([Cl:13])(=[O:16])=[O:15])[CH:5]=[CH:4][C:3]=1[O:8][C:9]([F:11])([F:10])[F:12]

参加物

5

反応物 2

HCID 24638Chlorosulfonic acidHCID 27772661-Bromo-2-(trifluoromethoxy)benzene

生成物 1

HCID 509980203-Bromo-4-(trifluoromethoxy)benzenesulfonyl chloride収率 77.7%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒3 回HCID 21907733Dichloromethane heptane溶媒

実験手順

2.0 g of 1-bromo-2-(trifluoro-methoxy)benzene (8.3 mmol) were dissolved in 30 ml of dichloromethane. At 0-5° C., 1.06 g of chlorosulfonic acid (9.13 mmol), dissolved in 3 ml of dichloromethane, were added dropwise. The reaction mixture was stirred for 30 min at room temperature. Additional 5.5 equivalents of chlorosulfonic in dichloromethane were added to drive the reaction to completion. Standard work-up was followed and silica gel chromatography with n-heptane-dichloromethane (6:4) as eluent gave 2.19 g of the title compound.

後処理

  1. additionwere added dropwise
  2. customthe reaction to completion

出典と根拠

ORDレコード
ord-054f0d9409e64f83985fa23ec603e13e
出典データセット
uspto-grants-2013_07
特許番号
US08486984B2

反応ノート

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