Water → HCID 178457108、化合物

反応式

[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH:7]([C:10]1[CH:15]=[CH:14][C:13]([S:16]([NH:19][C:20]2[CH:34]=[CH:33][C:23]3[NH:24][C:25]([CH2:27][NH:28][C:29](=O)[CH2:30][CH3:31])=[N:26][C:22]=3[CH:21]=2)(=[O:18])=[O:17])=[CH:12][CH:11]=1)([CH3:9])[CH3:8].O>C1COCC1>[CH:7]([C:10]1[CH:11]=[CH:12][C:13]([S:16]([NH:19][C:20]2[CH:34]=[CH:33][C:23]3[NH:24][C:25]([CH2:27][NH:28][CH2:29][CH2:30][CH3:31])=[N:26][C:22]=3[CH:21]=2)(=[O:17])=[O:18])=[CH:14][CH:15]=1)([CH3:8])[CH3:9]

参加物

実験手順

To a suspension of lithium-aluminiumhydride (180 mg, 4.79 mmol) in THF (5 ml, dried Al2O3) at −5-0° C. a solution of N-[5-(4-isopropyl-benzenesulfonylamino)-1H-benzoimidazol-2-ylmethyl]-propionamide (320 mg, 0.80 mmol) in THF (5 ml) was added. After complete addition the mixture was allowed to warm to room temperature and was heated to reflux for 2 h. At 0° C. THF and then water were added. The mixture was dried with Na2SO4. The filtered solution was evaporated in vacuo and the residue was purified by preparative HPLC (water/5% acetonitrile/0.1% acetic acid) to give the product as a yellow oil (10 mg, 3%).