Triethylamine → N-Indan-2-ylmethyl-propionamide
反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1NC.[CH2:12]([N:14](CC)CC)C.[C:19]([O:23]C(=O)CC)(=O)[CH2:20][CH3:21]>C1COCC1>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1][CH:2]1[CH2:12][NH:14][C:19](=[O:23])[CH2:20][CH3:21]参加物
5
実験手順
A solution of indan-2-yl-methylamine (5.55 g, 37.7 mmol) and triethylamine (5.67 g, 56.0 mmol) in 100 mL THF was stirred at 5° C. and propionic anhydride (5.15 g, 39.6 mmol) added dropwise. After the mixture was stirred for 18 h at room temperature, the solvent was removed and ethyl acetate/water were added. The organic layer was washed with water and dried over MgSO4. The filtrate was concentrated to give a brown oil (8.79 g, 97%).
後処理
- customthe solvent was removed
- additionethyl acetate/water were added
- washThe organic layer was washed with water
- dry with materialdried over MgSO4
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-8a3114eccd19451292f4db3d5a5a833c
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486984B2
反応ノート
読み込み中…