3-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran → 3-Amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran

HRID 450841ノート

反応式

HRID 450841 の反応式
[NH2:1][C:2]1[C:6]2[CH:7]=[C:8]([Cl:11])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:12](=[O:27])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19]CC1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[NH2:1][C:2]1[C:6]2[CH:7]=[C:8]([Cl:11])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:12](=[O:27])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[OH:19]

参加物

4

反応物 1

HCID 113034533-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran

生成物 1

HCID 587073613-Amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

3-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran (Example 1, 0.5 g, 1.3 mmol) in ethyl acetate (15 ml) is stirred at room temperature under an atmosphere of hydrogen in the presence of palladium on charcoal (0.025 g). After 3 h the mixture is filtered over Celite® and evaporated to dryness. Purification of the residue by chromatography yields the title compound, having a m.p. of 208-210° C.

後処理

  1. filtrationAfter 3 h the mixture is filtered over Celite®
  2. customevaporated to dryness
  3. customPurification of the residue by chromatography

出典と根拠

ORDレコード
ord-20fa3f48fa274d5ba5b0c9b6540c4feb
出典データセット
uspto-grants-2013_07
特許番号
US08486996B2

反応ノート

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