Bromine → 2-Bromo-6-phenylcyclohexanone

HRID 451398

反応式

HRID 451398 の反応式
[C:1]1([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:14]Br>C(Cl)(Cl)Cl>[Br:14][CH:9]1[CH2:10][CH2:11][CH2:12][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]1=[O:13]

参加物

4

反応物 2

HCID 24408BromineHCID 955922-Phenylcyclohexanone

生成物 1

HCID 127791292-Bromo-6-phenylcyclohexanone収率 38%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

反応条件

温度
0 °C

実験手順

To a solution of 2-phenyl-cyclohexanone (10.0 g, 57 mmol) in CHCl3 (20 mL) at −10° C. a solution of bromine (9.6 g, 3.1 mL, 60 mmol) in CHCl3 (10 mL) was added and the reaction mixture was allowed to warm to 0° C. After for 2 hours the solvent was evaporated, methanol (30 mL) was added to the residue, cooled to 0° C., stirred for 30 minutes and the white solid was filtered off to give the title compound as a white solid (5.48 g, 38%).

後処理

  1. customAfter for 2 hours the solvent was evaporated
  2. additionmethanol (30 mL) was added to the residue
  3. temperaturecooled to 0° C.
  4. filtrationthe white solid was filtered off

出典と根拠

ORDレコード
ord-f5f911b86ea04631a721f5a9248e2d3c
出典データセット
uspto-grants-2013_07
特許番号
US08486967B2

関連ノート

読み込み中…