Sodium Hydroxide → 1-(6-Methylpyrimidin-4-yl)piperidin-4-amine

HRID 451469ノート

反応式

HRID 451469 の反応式
Cl.Cl.[CH3:3][C:4]1[N:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12][CH2:11]2)[CH:5]=1.[OH-].[Na+]>C(Cl)Cl>[CH3:3][C:4]1[N:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12][CH2:11]2)[CH:5]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 673421331-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride

生成物 1

HCID 166433141-(6-Methylpyrimidin-4-yl)piperidin-4-amine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride (see example 30b, 2 g, 7.54 mmol) was neutralized with 2 N NaOH solution and CH2Cl2, the aqueous layers were extracted three times with CH2Cl2, the combines organic layers were dried over Na2SO4, filtered and the solvent was evaporated. The title compound was obtained as a brown oil (1.31 g, 90%).

後処理

  1. extractionthe aqueous layers were extracted three times with CH2Cl2
  2. dry with materialthe combines organic layers were dried over Na2SO4
  3. filtrationfiltered
  4. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-d1a97e2157054c4bac830b1e9fca58d2
出典データセット
uspto-grants-2013_07
特許番号
US08486967B2

反応ノート

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