Water → 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

HRID 45149

反応式

HRID 45149 の反応式
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH2:7])=[N:3]1.[CH2:8]([CH2:12][C:13](=O)[CH3:14])[C:9]([CH3:11])=O.O>C1(C)C=CC=CC=1.CC(O)=O>[CH3:14][C:13]1[N:7]([C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=2)[C:9]([CH3:11])=[CH:8][CH:12]=1

参加物

6

反応物 3

HCID 962Water2 回HCID 80352,5-HexanedioneHCID 1372541-Methyl-3-aminopyrazole

生成物 1

HCID 132489953-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 1140Toluene溶媒

実験手順

To a solution of 1-methyl-1H-pyrazol-3-amine (9.5 g, 98 mmol) and acetonylacetone (11.2 g, 98 mmol) in toluene (150 mL), AcOH (1.5 mL) is added, heated to reflux with a water separator until the formation of water ceased. Concentrated to dry. The residue is purified by flash column to give product.

後処理

  1. temperatureheated
  2. concentrationConcentrated
  3. customto dry
  4. customThe residue is purified by flash column
  5. customto give product

出典と根拠

ORDレコード
ord-0937fb3db8924a38996162cfa19c76bf
出典データセット
uspto-grants-2013_09
特許番号
US08541432B2

関連ノート

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