Water → 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole
反応式
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH2:7])=[N:3]1.[CH2:8]([CH2:12][C:13](=O)[CH3:14])[C:9]([CH3:11])=O.O>C1(C)C=CC=CC=1.CC(O)=O>[CH3:14][C:13]1[N:7]([C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=2)[C:9]([CH3:11])=[CH:8][CH:12]=1参加物
6
実験手順
To a solution of 1-methyl-1H-pyrazol-3-amine (9.5 g, 98 mmol) and acetonylacetone (11.2 g, 98 mmol) in toluene (150 mL), AcOH (1.5 mL) is added, heated to reflux with a water separator until the formation of water ceased. Concentrated to dry. The residue is purified by flash column to give product.
後処理
- temperatureheated
- concentrationConcentrated
- customto dry
- customThe residue is purified by flash column
- customto give product
出典と根拠
- ORDレコード
- ord-0937fb3db8924a38996162cfa19c76bf
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541432B2
反応ノート
読み込み中…