2-nitro-7-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazine → 7-Phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazin-2-ylamine

HRID 451493ノート

反応式

HRID 451493 の反応式
[N+:1]([C:4]1[N:18]=[C:7]2[O:8][CH2:9][CH2:10][CH:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:6]2[N:5]=1)([O-])=O>C(OCC)(=O)C.[Pd]>[C:12]1([CH:11]2[CH2:10][CH2:9][O:8][C:7]3=[N:18][C:4]([NH2:1])=[N:5][N:6]23)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

4

反応物 1

HCID 673366942-nitro-7-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazine

生成物 1

HCID 673361667-Phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazin-2-ylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-nitro-7-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazine (174 mg, 707 μmol) in ethyl acetate (7 mL) was added 10% Pd on carbon (17.4 mg, 164 μmol). The reaction was hydrogenated at room temperature under an atmosphere of hydrogen over night. The catalyst was filtered off and washed with ethyl acetate. The title compound was obtained as a white solid (143.3 mg, 94%) after stirring with diethyl ether.

後処理

  1. waitThe reaction was hydrogenated at room temperature under an atmosphere of hydrogen over night
  2. filtrationThe catalyst was filtered off
  3. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-e80a5848181c40dabc3d8c844b7d8edf
出典データセット
uspto-grants-2013_07
特許番号
US08486967B2

反応ノート

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