tert-Butyl 4-(benzylamino)-3,3-difluoropiperidine-1-carboxylate → tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate
反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14]CC2C=CC=CC=2)[C:10]([F:23])([F:22])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH2:14])[C:10]([F:23])([F:22])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
A suspension of 4-benzylamino-3,3-difluoro-piperidine-1-carboxylic acid tert-butyl ester (830 mg, 2.54 mmol), Pd/C (81.2 mg, 76.3 μmol) in MeOH (30 mL) was hydrogenated at room temperature for 14 hours. The catalyst was filtered off, washed thoroughly with MeOH and the solvents were evaporated. The title compound was obtained as colorless oil (601 mg, 100%).
後処理
- filtrationThe catalyst was filtered off
- washwashed thoroughly with MeOH
- customthe solvents were evaporated
出典と根拠
- ORDレコード
- ord-66d74a7158f648e38ec52602af190b5d
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486967B2
反応ノート
読み込み中…