Dichloromethane → 3-(4-Trifluoromethyl-cyclohex-1-enyl)-pyridin-2-ylamine

HRID 451583

反応式

HRID 451583 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7]C(=O)C(C)(C)C.[F:14][C:15]([F:24])([F:23])[CH:16]1[CH2:21][CH2:20][C:19](=O)[CH2:18][CH2:17]1.C(Cl)Cl>C(Cl)Cl.CO>[F:14][C:15]([F:24])([F:23])[CH:16]1[CH2:21][CH2:20][C:19]([C:3]2[C:2]([NH2:7])=[N:1][CH:6]=[CH:5][CH:4]=2)=[CH:18][CH2:17]1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 10515192-(Pivaloylamino)pyridineHCID 27774914-(Trifluoromethyl)cyclohexanone

生成物 1

HCID 673414503-(4-Trifluoromethyl-cyclohex-1-enyl)-pyridin-2-ylamine収率 26%

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

Prepared in analogy to example 262 step a-b), starting from N-(pyridin-2-yl)pivalamide and 4-(trifluoromethyl)cyclohexanone. 3-(4-Trifluoromethyl-cyclohex-1-enyl)-pyridin-2-ylamine was obtained after column chromatography on silica gel using a gradient from CH2Cl2 to CH2Cl2/MeOH 19:1 (v/v) as eluent as a white solid (yield: 26% over 2 steps).

後処理

  1. customPrepared in analogy to example 262 step a-b),

出典と根拠

ORDレコード
ord-38af24023a4e4d978a1f4dac4a21afb5
出典データセット
uspto-grants-2013_07
特許番号
US08486967B2

関連ノート

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