(R)-tert-butyl 3-((R)-1-(3-chlorophenyl)-1-(2-ethoxy-2-oxoethoxy)ethyl)piperidine-1-carboxylate → ethyl 2-((R)-1-(3-chlorophenyl)-1-((R)-piperidin-3-yl)ethoxy)acetate

HRID 451913ノート

反応式

HRID 451913 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C@@:8]([C@@H:17]2[CH2:22][CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]2)([O:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:9])[CH:5]=[CH:6][CH:7]=1>CC#N>[Cl:1][C:2]1[CH:3]=[C:4]([C@@:8]([C@@H:17]2[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]2)([O:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:9])[CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 59201464(R)-tert-butyl 3-((R)-1-(3-chlorophenyl)-1-(2-ethoxy-2-oxoethoxy)ethyl)piperidine-1-carboxylate

生成物 1

HCID 59201559ethyl 2-((R)-1-(3-chlorophenyl)-1-((R)-piperidin-3-yl)ethoxy)acetate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of (R)-tert-butyl 3-((R)-1-(3-chlorophenyl)-1-(2-ethoxy-2-oxoethoxy)ethyl)piperidine-1-carboxylate (0.0580 g, 0.136 mmol), 2 NHCl (50 mL), and CH3CN (50 mL) was vigorously stirred at rt for 24 h. After the reaction mixture was evaporated under reduced pressure, the crude product ethyl 2-((R)-1-(3-chlorophenyl)-1-((R)-piperidin-3-yl)ethoxy)acetate was directly used in the next step without further purification. MS ESI +ve m/z 328 (M+H).

後処理

  1. customAfter the reaction mixture was evaporated under reduced pressure
  2. customthe crude product ethyl 2-((R)-1-(3-chlorophenyl)-1-((R)-piperidin-3-yl)ethoxy)acetate was directly used in the next step without further purification

出典と根拠

ORDレコード
ord-294cfc7ebb864716a59f1c36a94f5412
出典データセット
uspto-grants-2013_07
特許番号
US08487108B2

反応ノート

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