Hydrazine hydrate (1:1) → 6-hydrazinyl-N,N-dimethylpyridine-3-sulfonamide

HRID 45223ノート

反応式

HRID 45223 の反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]([CH3:13])[CH3:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1.O.[NH2:15][NH2:16]>CCO>[NH:15]([C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]([CH3:13])[CH3:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1)[NH2:16]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 47298556-chloro-N,N-dimethylpyridine-3-sulfonamide

生成物 1

HCID 52676846-hydrazinyl-N,N-dimethylpyridine-3-sulfonamide収率 85.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A mixture of 1.9 g (8.8 mmol) of 6-chloro-N,N-dimethylpyridine-3-sulfonamide and 4.6 mL (91.5 mmol) of hydrazine monohydrate in 10 mL of EtOH is heated for 2 hours at 80° C. The precipitate obtained, after cooling to room temperature, is filtered off and then washed with 10 mL of EtOH and dried under vacuum. 1.62 g of 6-hydrazino-N,N-dimethylpyridine-3-sulfonamide are obtained in the form of a white powder.

後処理

  1. customThe precipitate obtained
  2. temperatureafter cooling to room temperature
  3. filtrationis filtered off
  4. washwashed with 10 mL of EtOH
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-03e3e2556767432c8364a95b97ccb0ce
出典データセット
uspto-grants-2013_09
特許番号
US08541455B2

反応ノート

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