O-Phenylenediamine → HCID 370919、化合物

HRID 452371ノート

反応式

HRID 452371 の反応式
[CH:1]([C:3]1[C:4](=[O:13])[NH:5][C:6]2[C:12]=1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=O.[C:14]1([NH2:21])[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH2:20].S(=O)(O)[O-].[Na+]>C(O)C.O>[N:20]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[NH:21][C:1]=1[C:3]1[C:4](=[O:13])[NH:5][C:6]2[C:12]=1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2

参加物

6

反応物 3

HCID 7243O-PhenylenediamineHCID 100350681,2-Dihydro-2-oxocyclohepta[b]pyrrole-3-carboxaldehydeHCID 23665763Sodium Bisulfite

生成物 1

HCID 370919HCID 370919、化合物収率 95%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

3-Formyl-1-azaazulen-2-one (0.1 mmol) was dissolved in a mixture of 10 mL ethanol and 5 mL water. o-Phenylenediamine (0.15 mmol) and sodium bisulfite (0.2 mmol) were then added and heat to reflux for 1 day. After working up, the residue was then purified by column chromatography to give 8.6 mg of A1, yield 95%.

後処理

  1. temperatureheat
  2. temperatureto reflux for 1 day
  3. customthe residue was then purified by column chromatography

出典と根拠

ORDレコード
ord-27e5d7a3657c45c3a61bb8a7c20df659
出典データセット
uspto-grants-2013_07
特許番号
US08492374B2

反応ノート

読み込み中…