Methyl iodide → N-{(1R,3S)-3-[(benzyloxy)methyl]cyclopentyl}-6-chloro-N-methylpyridine-3-sulfonamide
反応式
[CH3:1]N(C)C1C=C(C=CC=1)CC1C(=O)N(C2N=CC(S(N(CC)C3C=CC=CC=3)(=O)=O)=CC=2)NC=1C.[CH2:36]([O:43][CH2:44][C@H:45]1[CH2:49][CH2:48][C@@H:47]([NH:50][S:51]([C:54]2[CH:55]=[N:56][C:57]([Cl:60])=[CH:58][CH:59]=2)(=[O:53])=[O:52])[CH2:46]1)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1.CI>>[CH2:36]([O:43][CH2:44][C@H:45]1[CH2:49][CH2:48][C@@H:47]([N:50]([CH3:1])[S:51]([C:54]2[CH:55]=[N:56][C:57]([Cl:60])=[CH:58][CH:59]=2)(=[O:53])=[O:52])[CH2:46]1)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1参加物
4
実験手順
According to process 23.2, starting with 0.66 g of 4 N-{(1R,3S)-3-[(benzyloxy)methyl]cyclopentyl}-6-chloropyridine-3-sulfonamide and 0.22 mL of methyl iodide, 0.58 g of N-{(1R,3S)-3-[(benzyloxy)methyl]cyclopentyl}-6-chloro-N-methylpyridine-3-sulfonamide is obtained in the form of an oil.