化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → 2,6-dichloro-9-cyclohexyl-9H-purine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Iodocyclohexane | HCID 12289 | — |
| 反応物 | 2,6-Dichloropurine | HCID 5324412 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 2,6-dichloro-9-cyclohexyl-9H-purine | HCID 20341610 | 41% |
反応手順
2,6-Dichloropurine (1 mmol), powdered potasium carbonate (1 mmol) and cyclohexyliodide (4 mmol) were vigorously stirred in 5 mL DMSO overnight. After evaporation of the solvent the product was extracted (water/diethylether) and purified by column chromatography (silicagel/1% MeOH in CHCl3). Crystallization from methanol gave the product in yield 41%, mp 116-121° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08492391B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-608eba876df34e16a63e3cf3678de238 |
| 出典メモ | uspto-grants-2013_07 |