Hydrazine hydrate (1:1) → 1H-Indazole-5-carbohydrazide

HRID 452592ノート

反応式

HRID 452592 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([O:12]C)=O)=[CH:7][CH:8]=2)[CH:3]=[N:2]1.O.[NH2:15][NH2:16]>CO>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([NH:15][NH2:16])=[O:12])=[CH:7][CH:8]=2)[CH:3]=[N:2]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 22260640Methyl 1H-indazole-5-carboxylate

生成物 1

HCID 433489731H-Indazole-5-carbohydrazide収率 93.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of methyl 1H-indazole-5-carboxylate (5.02 g, 28.5 mmol) and hydrazine monohydrate (6.94 mL, 143 mmol) in methanol (50 mL) was heated under reflux for 48 hr. After cooling, the precipitate was collected by filtration, and washed with methanol to give the title compound (4.69 g, yield 93%) as colorless crystals.

後処理

  1. temperatureunder reflux for 48 hr
  2. temperatureAfter cooling
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with methanol

出典と根拠

ORDレコード
ord-6a95072bede44d8682fd7f7e4442b4ca
出典データセット
uspto-grants-2013_07
特許番号
US08492378B2

反応ノート

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