Hydrochloric Acid → 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid
反応式
C([N:4]1[C:8]2[N:9]=[CH:10][CH:11]=C(C#N)[C:7]=2[CH:6]=[CH:5]1)(=O)C.[OH-:15].[Na+].[CH2:17]([OH:19])[CH3:18].Cl>O>[NH:4]1[C:8]2[N:9]=[CH:10][CH:11]=[C:18]([C:17]([OH:15])=[O:19])[C:7]=2[CH:6]=[CH:5]1参加物
6
反応条件
- 温度
- 90 °C
実験手順
A mixture of 1-acetyl-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (1.80 g, 11.10 mmol), 2 M aqueous sodium hydroxide solution (25 mL) and ethanol (25 mL) was stirred at 90° C. for 16 hr. The reaction mixture was neutralized with hydrochloric acid and diluted with water. The precipitate was collected by filtration, and washed with water and diethyl ether to give the title compound (1.51 g, yield 84%) as pale-yellow crystals.
後処理
- filtrationThe precipitate was collected by filtration
- washwashed with water and diethyl ether
出典と根拠
- ORDレコード
- ord-0225558ae596489fab4eb4960642631b
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08492378B2
反応ノート
読み込み中…